Hyperhomocysteinemia, MTHFR 677C→T Polymorphism, and Stroke

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Hyperhomocysteinemia, MTHFR 677C3T Polymorphism, and Stroke

Hyperhomocysteinemia, MTHFR 677C3T Polymorphism, and Stroke To the Editor: We welcome the report from Madonna and co-workers examining the role of prothrombotic and homocysteine (Hcy) pathway polymorphisms in risk of ischemic stroke in young adults.1 We wish to comment on several issues raised by their article relating to the design of studies of genetic risk factors for complex phenotypes such...

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Hyperhomocysteinemia, MTHFR 677C-->T polymorphism, and stroke.

Hyperhomocysteinemia, MTHFR 677C3T Polymorphism, and Stroke To the Editor: We welcome the report from Madonna and co-workers examining the role of prothrombotic and homocysteine (Hcy) pathway polymorphisms in risk of ischemic stroke in young adults.1 We wish to comment on several issues raised by their article relating to the design of studies of genetic risk factors for complex phenotypes such...

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Comparison of homocysteinemia and MTHFR 677CT polymorphism with Framingham Coronary Heart Risk Score.

OBJECTIVE The Framingham Coronary Heart Disease Risk Score is an important clinical tool. The aim of this cross-sectional study was to compare plasma homocysteine levels and polymorphism 677CT MTHFR with this score to determine the utility of these new biomarkers in clinical practice. METHODS Plasma homocysteine levels determined by chemiluminescence and polymorphism 677CT MTHFR, detected by ...

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Hyperhomocysteinemia, MTHFR, and risk of vascular disease.

tables or figures and should relate solely to an article published in Circulation within the preceding 12 weeks. Authors of letters selected for publication will receive prepublication proofs, and authors of the article cited in the letter will be invited to reply. Replies must be signed by all authors listed in the original publication. Please submit three typewritten, double-spaced copies of ...

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Hyperhomocysteinemia and MTHFR gene 677 C>T polymorphism: questionable role in female infertility

Background: Homocysteine is an intermediate in methionine metabolism required for the biosynthesis of nucleic acids. Hyperhomocysteinemia affects various organ systems and also has been implicated as a risk factor for infertility. Elevated levels result either from genetic mutations of the enzymes catalyzing the metabolic pathway or deficiency of micronutrients required as co-enzymes for the sa...

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ژورنال

عنوان ژورنال: Stroke

سال: 2002

ISSN: 0039-2499,1524-4628

DOI: 10.1161/01.str.0000018602.09015.c1